Tempo Pharmaceuticals

In recent years, focus heavily on pharmaceutical research in the use of fluoride in written form around 1990, were approximately 220 fluorinated pharmaceuticals in use that are almost 8% of the market for synthetic drugs. Since then, the use of fluorinated pharmaceuticals has increased rapidly. These fluorinated compounds are increasingly important in the modern pharmaceutical industry, and currently 30% to 50% of all drugs fluorochemicals.

Recent pharmaceutical applications of fluorinated compounds

Fluorinated compounds are available in a variety of medications, including the following types of products available:

Anesthesia

* antacids
* Nonsteroidal anti-fungal and antibiotic
* Antidepressants, antipsychotics and anxiolytics
and anti-inflammatory drugs
* Antimalarials

* Cholesterol Reducer
* Chemotherapeutics for cancer treatment

a look at some common pharmaceutical applications

Two of the most commonly prescribed antidepressants fluorinated compounds. These are Prozac and Paxil, antidepressants prescribed in the third and the fifth most common in the U.S., respectively. Both are called “selective inhibitors of serotonin reuptake,” which means the transmission by preventing presynaptic serotonin neurons Somal is known to work. This means, Prozac and Paxil to stimulate a higher level of serotonin available to neurons in the brain, symptoms of depression.

Another common use of fluorine in chemotherapy to treat certain types of cancer. A chemotherapy agent called fluorouracil, which belongs to a family of drugs known as anti-metabolites, is used in cancer treatment 40th

Fluorouracil is an analogue of a molecule called uracil, which is used by every cell of DNA replication. Fluorinated analogue of the growth of cancer cells by interrupting the uracil as naturally occurring cells and prevents the synthesis of new DNA molecules that are required for replication. Although it is also healthy noncancerous cells act fluorouracil, which is absorbed and used for rapid in cancer cells. Fluorouracil is primarily used to treat pancreatic cancer and colorectal cancer, which has for several decades, used in combination with other chemotherapy drugs known leucovorin.

Anti-bacterial agents and anti-fungal such as ciprofloxacin and fluconazole or also known fluoride compounds. Ciprofloxacin works by preventing adequate cell bacterial synthesis of new DNA molecules, which in turn prevents cells from dividing. Unlike many other antibacterial agents active against Gram-positive and Gram-negative ciprofloxacin be significantly greater range of applications. Fluconazole inhibits the function of an enzyme called cytochrome P450 fungus that inhibits the growth of yeast cells due to the instability of cell membranes.

the growing popularity of fluorinated pharmaceuticals

Interestingly, the fluoro-organic compounds are rarely found in nature, and the few that exist are highly toxic. Why are so many fluorinated compounds used in the pharmaceutical industry? There are several reasons for the widespread use of fluorinated pharmaceuticals.

The first important factor is that fluorinated organic compounds are bioactive.
Second, the introduction of fluoride in a bioactive compound that does not improve the list, the pharmacological properties of this compound in many cases. Simply by fluorine, many medications can be stronger, which means that a lower dose should be used to achieve the same effect.

Third, change the addition of fluoride to the bioactive compounds are usually not significant. This is a crucial factor in the pharmaceutical industry, and this change may come in the form of a bioactive compound power, or completely inhibit the bioactivity.

The fourth characteristic of fluorinated pharmaceuticals, is that the addition of fluoride to increase the stability of these products formed due to strong covalent bonding between carbon and fluorine. However, it should be noted that this can be inconvenient at times, as this increased stability of the metabolism of drugs may reduce some fluorinated.

Finally, the increasing ease of use of fluorinated compounds is also notable. In its elemental form, fluoride is a highly reactive and toxic gases, which has restricted their use to specially equipped laboratories in the past. But in recent years in specialized equipment for the production and handling of fluoride everywhere.

Since the use of fluoride has become more common, the range of possible applications has increased dramatically. For example, in many cases be able to fluoride is now known that pharmaceutical products with chlorine or bromine, with relative ease, can increase its effectiveness can be replaced.